Endocrine Abstracts

Objective: To investigate long-term effects of GH replacement therapy.Material and methods: Thirty-nine patients (mean age 52.5 years, 14 women) with adult-onset growth hormone deficiency (AOGHD), recruited from a randomized placebo-controlled crossover study of treatment with growth hormone (GH) and placebo for 9months each, were enrolled in an open prospective follow up study. GH replacement was given for additional thirty-three months and was individu...

Background: Testosterone therapy in transgender men (TM) is aimed at achieving serum testosterone levels in the male reference range. It remains unknown if serum oestradiol levels in TM should be evaluated and/or adjusted. Although reported serum oestradiol levels in TM are variable in the current literature, these values may be affected through two possible mechanisms: serum oestradiol levels may increase through aromatization of exogenous testosterone, while the effects of e...

Objective: Hormonal treatment in trans women (MtF transgender persons) in Europe usually consists of estrogens and anti-androgens, e.g. cyproterone acetate (CPA). After initiation of cross-sex hormone therapy, an elevation in serum prolactin levels is frequently observed in trans women, which was previously attributed to estrogen agents. This analysis evaluates whether CPA contributes to the elevation of prolactin in trans women receiving cross-sex hormones.<p class="abste...

Introduction: Fat distribution is an important secondary sex characteristic, which is generally peripherally or pear-shaped (gynoid) in females and centrally or apple-shaped (android) in males. Total body fat increases in male-to-females (MtFs) and decreases in female-to-males (FtMs) during cross-sex hormone therapy (CSHT), approaching body fat amounts of the desired sex. However, changes in android or gynoid fat distribution might be a better measure for masculinization and f...

Introduction: Gender differences in insulin resistance, body composition and lipid profile are well known and related to sex steroid hormones. In this study, we examine the metabolic profile of transsexual persons undergoing drastic sex steroid changes, during the first year of hormonal therapy.Design: This research is part of a prospective intervention study conducted in several European gender teams (Ghent, Oslo, Amsterdam, and Florence).<p class="...

Introduction: Prader–Willi syndrome (PWS) presents clinically with a multitude of findings, including abnormal body composition and partial GH deficiency. Until now three studies have reported beneficial effects upon body composition of GH treatment in adults with PWS. However, only one of these studies had the optimal randomised controlled design.Aim: The aim of this study was to confirm and substantiate the results from previous studies.<p cla...

Introduction: Anger is an emotional state of feelings varying from mild irritation to intense rage, whereas aggression implies externalizing angry emotions through destructive/ punitive behavior towards other persons/objects. Although research on the relationship between testosterone and aggression is inconclusive, the WPATH SOC 7 guidelines have warned for an increase in aggression in transgender men (TM) taking testosterone treatment.Aims:<p class=...

Introduction: Estrogen has positive effects on bone mineral density (BMD), in particular in trabecular bone through inhibition of bone resorption. Testosterone increases bone size, but the effect on BMD is less clear. Cross-sex hormonal treatment (CSHT) in transgender individuals can affect BMD. Therefore, the aim of this study is to investigate effects of CSHT on BMD during the first year of treatment in male-to-female (MtFs) and female-to-male (FtMs) transgender persons....

Background: Persistent vaginal bleeding can be psychologically stressful and incongruent with gender identity in transgender men (assigned female at birth with male gender identity). Previous studieshave cross-sectionally described amenorrhea in cohorts of transgender men on intramuscular or subcutaneous testosterone injections. It remains uncertain which testosterone preparations most effectively suppress vaginal bleeding and when amenorrhea occurs after testosterone initiati...